4-(1-Imidazolyl)benzoic Acid → HCID 58614654, compound

HRID 923045Notes

Reaction equation

HRID 923045 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.[N:15]1([C:20]2[CH:28]=[CH:27][C:23]([C:24](O)=[O:25])=[CH:22][CH:21]=2)[CH:19]=[CH:18][N:17]=[CH:16]1>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:24](=[O:25])[C:23]2[CH:22]=[CH:21][C:20]([N:15]3[CH:19]=[CH:18][N:17]=[CH:16]3)=[CH:28][CH:27]=2)=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1

Participants

3

Reactant 2

HCID 7365294-(1-Imidazolyl)benzoic AcidHCID 401519254-Chloro-3-(pyridin-2-yl)aniline

Product 1

HCID 58614654HCID 58614654, compound

Procedure

75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 78 mg of 4-(1H-imidazol-1-yl)benzoic acid via Procedure G. The crude product was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(1H-imidazol-1-yl)benzamide. MS (Q1) 375.3 (M)+.

Workup

  1. customThe crude product was purified by reverse phase HPLC

Sources & evidence

ORD record
ord-108907792095429fb3ec8da68c0c4b94
Source dataset
uspto-grants-2016_03
Patent number
US09278961B2

Reaction notes

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