反应详情

温度

50 °C

N-(3-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-4-methylbenzamide (0.94 mmol) can be suspended in MeCN (10 ml) and heated with stirring to a temperature of 45 to 55° C. (hot plate temperature). Hydrochloric acid (1.1 eq 1M solution in EtOH) is added to obtain dissolution. Within a few minutes, a precipitate is allowed to form. The suspension can be cooled to ambient temperature and then filtered and washed with MeCN (1×1.5 ml liquors+1×1.5 ml fresh). The solid can be dried at 50° C. under vacuum to constant weight.

1. temperatureheated
2. customto obtain
3. dissolutiondissolution
4. waitWithin a few minutes
5. customto form
6. temperatureThe suspension can be cooled to ambient temperature
7. filtrationfiltered
8. washwashed with MeCN (1×1.5 ml liquors+1×1.5 ml fresh)
9. customThe solid can be dried at 50° C. under vacuum to constant weight