Water → HCID 178437551, compound

HRID 923316Notes

Reaction equation

HRID 923316 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]3[NH:14][C:15]4[N:16]([N:20]=[C:21]([CH2:23][CH3:24])[N:22]=4)[C:17](=[O:19])[CH:18]=3)=[CH:10][CH:11]=2)[CH:6]=[N:5]1)(=O)C.C(=O)([O-])[O-].[K+].[K+].O>CO>[CH2:23]([C:21]1[N:22]=[C:15]2[NH:14][C:13]([C:9]3[CH:8]=[C:7]4[C:12](=[CH:11][CH:10]=3)[NH:4][N:5]=[CH:6]4)=[CH:18][C:17](=[O:19])[N:16]2[N:20]=1)[CH3:24]

Participants

5

Reactant 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 1784375505-(1-acetyl-1H-indazol-5-yl)-2-ethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one

Product 1

HCID 178437551HCID 178437551, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 5-(1-acetyl-1H-indazol-5-yl)-2-ethyl-[1,2,4]triazolo[1,5-α]pyrimidin-7(4H)-one (130 mg, crude) in methanol (5 ml) was added potassium carbonate (20 mg, 0.14 mmol) and water (1 ml), and the reaction mixture was stirred overnight at room temperature. The reaction mixture was concentrated under vacuum and diluted with water (10 ml). The product was collected by filtration and washed with ethanol (10 ml) to afford 2-ethyl-5-(1H-indazol-5-yl)-[1,2,4]triazolo[1,5-α]pyrimidin-7(4H)-one as a yellow solid (66 mg, 18% 2 steps).

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. additiondiluted with water (10 ml)
  3. filtrationThe product was collected by filtration
  4. washwashed with ethanol (10 ml)

Sources & evidence

ORD record
ord-6da2e22ababf4e22ba7b0f0ca1617bb5
Source dataset
uspto-grants-2016_03
Patent number
US09278973B2

Reaction notes

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