HCID 178473134, compound → HCID 178508560, compound

HRID 923319Notes

Reaction equation

HRID 923319 reaction equation
C([O:3][C:4](=[O:12])[C:5]([NH:7][NH:8][C:9](=[NH:11])[NH2:10])=O)C>O>[NH2:10][C:9]1[NH:8][N:7]=[C:5]([C:4]([OH:3])=[O:12])[N:11]=1

Participants

3

Reactant 1

HCID 178473134HCID 178473134, compound

Product 1

HCID 178508560HCID 178508560, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of ethyl 2-(2-carbamimidoylhydrazinyl)-2-oxoacetic acid (2 g, 35.60 mmol) in water (100 ml) was stirred for 12 h at 100° C. The resulting mixture was concentrated under vacuum to give a residue, which was precipitated from water (10 ml) to afford 5-amino-1H-1,2,4-triazole-3-carboxylic acid as a white solid (1.1 g, 63%).

Workup

  1. concentrationThe resulting mixture was concentrated under vacuum
  2. customto give a residue, which
  3. customwas precipitated from water (10 ml)

Sources & evidence

ORD record
ord-66f730ea2d444e98a07c5f6d03710d8d
Source dataset
uspto-grants-2016_03
Patent number
US09278973B2

Reaction notes

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