HCID 178513170, compound → HCID 178508293, compound

HRID 923339Notes

Reaction equation

HRID 923339 reaction equation
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([NH:8][NH:9][C:10](=[NH:12])[NH2:11])=O)=[CH:4][CH:3]=1>C1(OC2C=CC=CC=2)C=CC=CC=1>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]2[N:11]=[C:10]([NH2:12])[NH:9][N:8]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 178513170HCID 178513170, compound

Product 1

HCID 178508293HCID 178508293, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

A solution of 2-(4-chlorobenzoyl)hydrazinecarboximidamide (2.1 g) in diphenylether (15 ml) was stirred for 10 min at 170° C. The reaction was then quenched by the addition of hexane (30 ml) and the product was collected by filtration, washed with hexane (3×10 ml) and dried in an oven under reduced pressure to give 3-(4-chlorophenyl)-1H-1,2,4-triazol-5-amine as a light yellow solid (1 g, 52%).

Workup

  1. customThe reaction was then quenched by the addition of hexane (30 ml)
  2. filtrationthe product was collected by filtration
  3. washwashed with hexane (3×10 ml)
  4. customdried in an oven under reduced pressure

Sources & evidence

ORD record
ord-d9706ef98e20457bb1b94578c127c728
Source dataset
uspto-grants-2016_03
Patent number
US09278973B2

Reaction notes

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