Potassium Carbonate → HCID 178515494, compound

HRID 923346Notes

Reaction equation

HRID 923346 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]3[NH:14][C:15]4[N:16]([N:20]=[C:21]([C:23]5[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=5)[N:22]=4)[C:17](=[O:19])[CH:18]=3)=[CH:10][CH:11]=2)[CH:6]=[N:5]1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[F:29][C:26]1[CH:27]=[CH:28][C:23]([C:21]2[N:22]=[C:15]3[NH:14][C:13]([C:9]4[CH:8]=[C:7]5[C:12](=[CH:11][CH:10]=4)[NH:4][N:5]=[CH:6]5)=[CH:18][C:17](=[O:19])[N:16]3[N:20]=2)=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 1784739865-(1-acetyl-1H-indazol-5-yl)-2-(4-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one

Product 1

HCID 178515494HCID 178515494, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 5-(1-acetyl-1H-indazol-5-yl)-2-(4-fluorophenyl)-[1,2,4]triazolo[1,5-α]pyrimidin-7(4H)-one (100 mg, crude) in methanol (10 ml) was added a solution of potassium carbonate (50 mg, 0.36 mmol), and the resulting mixture was stirred overnight at room temperature. The solids were collected by filtration and washed with water (3 ml) and methanol (10 ml) to afford 2-(4-fluorophenyl)-5-(1H-indazol-5-yl)-[1,2,4]triazolo[1,5-α]pyrimidin-7(4H)-one as a light yellow solid (55 mg, 23% 2 steps).

Workup

  1. filtrationThe solids were collected by filtration
  2. washwashed with water (3 ml) and methanol (10 ml)

Sources & evidence

ORD record
ord-644990e2d4a14ab49eebd481d9792d17
Source dataset
uspto-grants-2016_03
Patent number
US09278973B2

Reaction notes

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