2-Methylbenzoic acid → 2-Methylbenzoyl chloride

HRID 923352Notes

Reaction equation

HRID 923352 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:13])=O>>[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:13])=[O:5]

Participants

3

Reactant 2

HCID 83732-Methylbenzoic acidHCID 24386Thionyl Chloride

Product 1

HCID 702762-Methylbenzoyl chloride

Procedure

A solution of 2-methylbenzoic acid (10 g, 1.00 equiv) in thionyl chloride (50 mL) was refluxed overnight at 80° C. in an oil bath. The reaction mixture was concentrated under vacuum to afford 2-methylbenzoyl chloride (crude) as a colorless oil.

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-f8810eb9d488428ba8a3537d311d86c5
Source dataset
uspto-grants-2016_03
Patent number
US09278973B2

Reaction notes

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