Trifluoroacetic acid → HCID 66810490, compound

HRID 923373Notes

Reaction equation

HRID 923373 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][C@@H:12]([N:14]2[CH2:21][C:20]3[CH2:19][NH:18][N:17]([S:22]([CH:25]4[CH2:29][CH2:28][CH2:27][CH2:26]4)(=[O:24])=[O:23])[C:16]=3[CH2:15]2)[CH2:11][O:10][C@@H:9]1[C:30]1[CH:35]=[C:34]([F:36])[CH:33]=[CH:32][C:31]=1[F:37])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[F:37][C:31]1[CH:32]=[CH:33][C:34]([F:36])=[CH:35][C:30]=1[C@@H:9]1[C@@H:8]([NH2:7])[CH2:13][C@@H:12]([N:14]2[CH2:21][C:20]3[CH2:19][NH:18][N:17]([S:22]([CH:25]4[CH2:29][CH2:28][CH2:27][CH2:26]4)(=[O:23])=[O:24])[C:16]=3[CH2:15]2)[CH2:11][O:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86641697HCID 86641697, compound

Product 1

HCID 66810490HCID 66810490, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the intermediate obtained in Step A above (49 mg, 0.089 mmol) in dichloromethane (4 mL) was treated with trifluoroacetic acid (2 mL) at room temperature. After 1.5 h, the reaction mixture was concentrated and purified by preparative thin layer chromatography eluting with 5% methanol containing 10% NH4OH in dichloromethane to give the title compound.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. custompurified by preparative thin layer chromatography
  3. washeluting with 5% methanol containing 10% NH4OH in dichloromethane

Sources & evidence

ORD record
ord-52a491d771704b42a0b0c25250d08707
Source dataset
uspto-grants-2016_03
Patent number
US09278976B2

Reaction notes

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