Trifluoroacetic acid → (R)-2-phenyl-2-(piperidin-1-yl)acetic acid

HRID 923412Notes

Reaction equation

HRID 923412 reaction equation
[C:1]1([C@@H:7]([N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[C:8]([O:10]C(C)(C)C)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)(C(F)(F)F)=O>>[C:1]1([C@@H:7]([N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[C:8]([OH:10])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59166413HCID 59166413, compound

Product 1

HCID 1090523(R)-2-phenyl-2-(piperidin-1-yl)acetic acid

Procedure

The product from Example 92A was treated with TFA (1.5 mL) at rt for 3 h. The volatiles were removed under vacuum, the residue concentrated from toluene (×2) and dried in a vacuum oven to give title compound which was used without further purification. MS (DCI; M+H) m/z=220.

Workup

  1. customThe volatiles were removed under vacuum
  2. concentrationthe residue concentrated from toluene (×2)
  3. customdried in a vacuum oven

Sources & evidence

ORD record
ord-a5b2d71ed6074ce386e3a9f264b4284b
Source dataset
uspto-grants-2016_03
Patent number
US09278922B2

Reaction notes

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