Diethylamine → HCID 178502344, compound

HRID 923419Notes

Reaction equation

HRID 923419 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH2:36][C:37]2[CH:42]=[CH:41][C:40]([NH:43][C:44]([C@H:46]3[CH2:50][CH2:49][CH2:48][N:47]3C(OCC3C4C=CC=CC=4C4C3=CC=CC=4)=O)=[O:45])=[CH:39][CH:38]=2)[CH2:9][C:10]2[CH:35]=[CH:34][C:13]3[NH:14][C:15]([C@@H:17]4[CH2:21][CH2:20][CH2:19][N:18]4[C:22](=[O:33])[C@@H:23]([NH:28][C:29]([O:31][CH3:32])=[O:30])[C:24]([OH:27])([CH3:26])[CH3:25])=[N:16][C:12]=3[CH:11]=2)=[CH:4][CH:3]=1.C(NCC)C>C(#N)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH2:9][C:10]2[CH:35]=[CH:34][C:13]3[NH:14][C:15]([C@@H:17]4[CH2:21][CH2:20][CH2:19][N:18]4[C:22](=[O:33])[C@@H:23]([NH:28][C:29](=[O:30])[O:31][CH3:32])[C:24]([OH:27])([CH3:25])[CH3:26])=[N:16][C:12]=3[CH:11]=2)[CH2:36][C:37]2[CH:42]=[CH:41][C:40]([NH:43][C:44]([C@H:46]3[CH2:50][CH2:49][CH2:48][NH:47]3)=[O:45])=[CH:39][CH:38]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 178502345HCID 178502345, compound

Product 1

HCID 178502344HCID 178502344, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The product from Example 99G (0.115 g, 0.127 mmol) was dissolved in acetonitrile (2 mL) at ambient temperature and treated with diethylamine (1 mL) for 1 hour. The solution was concentrated to dryness to give the crude title compound.

Workup

  1. concentrationThe solution was concentrated to dryness

Sources & evidence

ORD record
ord-4eef1c3c5fc14771b483b46d50147392
Source dataset
uspto-grants-2016_03
Patent number
US09278922B2

Reaction notes

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