(S)-N-(4-(((4-fluorophenyl)(4-((S)-pyrrolidine-2-carboxamido)benzyl)amino)methyl)phenyl)-1-((R)-2-phenyl-2-(piperidin-1-yl)acetyl)pyrrolidine-2-carboxamide → methyl {(1S)-2-{(2S)-2-[(4-{[(4-fluorophenyl){4-[({(2S)-1-[(2R)-2-phenyl-2-piperidin-1-ylacetyl]pyrrolidin-2-yl}carbonyl)amino]benzyl}amino]methyl}phenyl)carbamoyl]pyrrolidin-1-yl}-2-oxo-1-[(3R)-tetrahydrofuran-3-yl]ethyl}carbamate

Participants

Reaction Steps

The product from Example 114C (0.040 g, 0.056 mmol) and (S)-2-(methoxycarbonylamino)-2-((R)-tetrahydrofuran-3-yl)acetic acid (0.014 g, 0.067 mmol) were processed as in Example 81A to give the title compound. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.29-1.38 (m, 2 H) 1.39-1.47 (m, 4 H) 1.68-1.78 (m, 1 H) 1.79-1.90 (m, 4 H) 1.93-2.06 (m, 4 H) 2.10-2.22 (m, 1 H) 3.14-3.25 (m, 1 H) 3.41-3.50 (m, 4 H) 3.53 (s, 3 H) 3.58-3.70 (m, 4 H) 3.71-3.79 (m, 2 H) 3.80-3.90 (m, 2 H) 4.20-4.28 (m, 2 H) 4.31 (dd, J=7.64, 4.07 Hz, 1 H) 4.44 (dd, J=7.97, 4.93 Hz, 1 H) 4.56 (s, 4 H) 6.64 (dd, J=9.22, 4.34 Hz, 2 H) 6.91 (t, J=8.95 Hz, 2 H) 7.18 (d, J=8.13 Hz, 4 H) 7.25-7.37 (m, 3 H) 7.42 (d, J=6.83 Hz, 2 H) 7.51 (dd, J=8.57, 1.84 Hz, 4 H) 7.60 (d, J=8.02 Hz, 1 H) 9.96 (s, 1 H) 9.98 (s, 1 H); MS ESI− m/z 900.6 (M−H)−.

Provenance & Evidence