反应详情

To a solution of 228 mg of ethyl [(diphenylmethylene)amino](1-methyl-1H-pyrazol-4-yl)acetate in 2.8 ml of 1,4-dioxane was added 1.9 ml of 1 M hydrochloric acid, followed by stirring at room temperature for 2.5 hours. The reaction mixture was concentrated under reduced pressure, the obtained residue was washed with diethyl ether, and to the aqueous layer was added a saturated aqueous sodium hydrogen carbonate solution, followed by extraction with chloroform. The organic layer was dried over anhydrous magnesium sulfate and the solvent was then evaporated under reduced pressure to obtain 91 mg of ethyl amino(1-methyl-1H-pyrazol-4-yl)acetate.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. washthe obtained residue was washed with diethyl ether
3. additionto the aqueous layer was added a saturated aqueous sodium hydrogen carbonate solution
4. extractionfollowed by extraction with chloroform
5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
6. customthe solvent was then evaporated under reduced pressure