Tetrahydrofuran → HCID 118308707, compound

HRID 923496Notes

Reaction equation

HRID 923496 reaction equation
[CH3:1][C:2]1([CH3:19])[O:7][CH2:6][C:5]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][N:13]=2)([C:8]([O:10]C)=[O:9])[CH2:4][O:3]1.C1COCC1.[OH-].[Na+:26]>CO>[CH3:1][C:2]1([CH3:19])[O:7][CH2:6][C:5]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][N:13]=2)([C:8]([O-:10])=[O:9])[CH2:4][O:3]1.[Na+:26]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 118308778HCID 118308778, compound

Product 1

HCID 118308707HCID 118308707, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To a mixture of 1.17 g of methyl 2,2-dimethyl-5-(5-methylpyridin-2-yl)-1,3-dioxane-5-carboxylate, 14 ml of THF, and 14 ml of methanol was added 4.7 ml of a 1 M aqueous sodium hydroxide solution, followed by stirring at 50° C. for 20 hours. The reaction mixture was left to be cooled to room temperature and the solvent was then evaporated under reduced pressure to obtain 1.19 g of sodium 2,2-dimethyl-5-(5-methylpyridin-2-yl)-1,3-dioxane-5-carboxylate.

Workup

  1. waitThe reaction mixture was left
  2. temperatureto be cooled to room temperature
  3. customthe solvent was then evaporated under reduced pressure

Sources & evidence

ORD record
ord-207bac72a4ec4caa80c1601cd908c749
Source dataset
uspto-grants-2016_03
Patent number
US09278968B2

Reaction notes

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