Hydrogen chloride-ethyl acetate → HCID 118308782, compound

Participants

Reaction Steps

To a suspension of 1.28 g of 8-(cyclohexylmethoxy)-N-[(1R)-2-hydroxy-1-phenylethyl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide prepared by the same method as in Example 1, which will be described later, in 30 ml of ethyl acetate was added 1.2 ml of a 4 M hydrogen chloride/ethyl acetate solution, followed by stirring at room temperature. The insoluble materials were collected by filtration and dried under reduced pressure to obtain 1.41 g of 8-(cyclohexylmethoxy)-N-[(1R)-2-hydroxy-1-phenylethyl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide hydrochloride.

Provenance & Evidence