Hydrogen chloride-ethyl acetate → HCID 118308782, compound

HRID 923497Notes

Reaction equation

HRID 923497 reaction equation
[CH:1]1([CH2:7][O:8][C:9]2[C:10]3[N:11]([C:15]([C:19]([NH:21][C@H:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH2:23][OH:24])=[O:20])=[C:16]([CH3:18])[N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:31].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:31].[CH:1]1([CH2:7][O:8][C:9]2[C:10]3[N:11]([C:15]([C:19]([NH:21][C@H:22]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH2:23][OH:24])=[O:20])=[C:16]([CH3:18])[N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 71478861HCID 71478861, compound

Product 1

HCID 118308782HCID 118308782, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a suspension of 1.28 g of 8-(cyclohexylmethoxy)-N-[(1R)-2-hydroxy-1-phenylethyl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide prepared by the same method as in Example 1, which will be described later, in 30 ml of ethyl acetate was added 1.2 ml of a 4 M hydrogen chloride/ethyl acetate solution, followed by stirring at room temperature. The insoluble materials were collected by filtration and dried under reduced pressure to obtain 1.41 g of 8-(cyclohexylmethoxy)-N-[(1R)-2-hydroxy-1-phenylethyl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide hydrochloride.

Workup

  1. customprepared by the same method as in Example 1, which
  2. filtrationThe insoluble materials were collected by filtration
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-12533c156f5c455c8e67ae46e1c9448f
Source dataset
uspto-grants-2016_03
Patent number
US09278968B2

Reaction notes

Loading…