Sulfuric Acid → Pyridinoisothiazolone

HRID 923633Notes

Reaction equation

HRID 923633 reaction equation
S[C:2]1[N:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:3]=1C#N.SC1N=C(C)C=C(C)C=1C#[N:15].O[S:23]([OH:26])(=O)=O>>[S:23]1(=[O:26])[C:7]2[CH:6]=[CH:3][CH:2]=[N:9][C:8]=2[CH:10]=[N:15]1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 178425247HCID 178425247, compoundHCID 178425618HCID 178425618, compound

Product 1

HCID 57790288Pyridinoisothiazolone

Procedure

treating 2-mercapto-6-methylnicotinonitrile and 2-mercapto-4,6-dimethylnicotinonitrile in concentrated H2SO4 at 100° C. to give pyridinoisothiazolone compounds 3 (R1═H, R2=Me) and 4 (R1═R2=Me), respectively;

Sources & evidence

ORD record
ord-f3d5fd9daa784428bff1da7a6cb278e0
Source dataset
uspto-grants-2016_03
Patent number
US09278982B2

Reaction notes

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