Sodium Iodide → Tert-butyl 4-(2-iodoacetyl)piperazine-1-carboxylate

HRID 923634Notes

Reaction equation

HRID 923634 reaction equation
Cl[CH2:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7][CH2:6]1)=[O:4].[I-:18].[Na+]>CC(C)=O>[I:18][CH2:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7][CH2:6]1)=[O:4]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 15829156Tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate

Product 1

HCID 67174982Tert-butyl 4-(2-iodoacetyl)piperazine-1-carboxylate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

treating tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate with sodium iodide in acetone to give the corresponding iodo compound, tert-butyl 4-(2-iodoacetyl)piperazine-1-carboxylate;

Sources & evidence

ORD record
ord-7c89a796a9534094bc9532170674e04b
Source dataset
uspto-grants-2016_03
Patent number
US09278982B2

Reaction notes

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