HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(-)-N-Boc-prolinol → 1,1-Dimethylethyl (2S,4S)-4-(((1,1-dimethylethyl)dimethylsilyl)oxy)-2-formyl-1-pyrrolidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(-)-N-Boc-prolinol | HCID 643448 | — |
| Reactant | tert-butyl (2S,4S)-4-[tert-butyl(dimethyl)silyl]oxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate | HCID 58303448 | — |
| Product | 1,1-Dimethylethyl (2S,4S)-4-(((1,1-dimethylethyl)dimethylsilyl)oxy)-2-formyl-1-pyrrolidinecarboxylate | HCID 57754007 | — |
Reaction Steps
With the exception that N-t-butoxycarbonyl-cis-4-(t-butyldimethylsilyl)oxy-L-prolinol, instead of N-t-butoxycarbonyl-L-prolinol, was used, the same procedure as in Preparation Example 1-1 was repeated to afford the title compound. 3.8 g (52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278996B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-026e420b7dd74a0396f2a7ffa73d718e |
| Source note | uspto-grants-2016_03 |