(2,6-Difluorophenyl)acetonitrile → 2-(2,6-Difluorophenyl)ethan-1-amine

HRID 923711Notes

Reaction equation

HRID 923711 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][C:10]#[N:11].B.[K]>[Ni].C(O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][CH2:10][NH2:11]

Participants

5

Reactant 2

HCID 69559(2,6-Difluorophenyl)acetonitrileHCID 24201897CID 24201897

Product 1

HCID 37461112-(2,6-Difluorophenyl)ethan-1-amine

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

2-(2,6-Difluorophenyl)acetonitrile (2.34 g, 15.28 mmol) was added to potassium boron hydride (3.29 g, 61.12 mmol) and Raney nickel (0.897 g, 15.28 mmol) in 50 mL of absolute ethanol while stirring. Then, vigorously stirring was continued at room temperature for 5 hrs.

Workup

  1. stirringThen, vigorously stirring

Sources & evidence

ORD record
ord-221ef204e1834e04a19559ff976f0496
Source dataset
uspto-grants-2016_03
Patent number
US09278996B2

Reaction notes

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