HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2,6-Difluorophenyl)acetonitrile → 2-(2,6-Difluorophenyl)ethan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2,6-Difluorophenyl)acetonitrile | HCID 69559 | — |
| Reactant | CID 24201897 | HCID 24201897 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(2,6-Difluorophenyl)ethan-1-amine | HCID 3746111 | — |
Reaction Steps
2-(2,6-Difluorophenyl)acetonitrile (2.34 g, 15.28 mmol) was added to potassium boron hydride (3.29 g, 61.12 mmol) and Raney nickel (0.897 g, 15.28 mmol) in 50 mL of absolute ethanol while stirring. Then, vigorously stirring was continued at room temperature for 5 hrs.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278996B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-221ef204e1834e04a19559ff976f0496 |
| Source note | uspto-grants-2016_03 |