2-Methylpyridine-3-boronic acid → HCID 118195140, compound

HRID 923861Notes

Reaction equation

HRID 923861 reaction equation
Br[C:2]1[C:3]([N:22]2[CH2:26][CH2:25][C@@H:24]([OH:27])[CH2:23]2)=[N:4][CH:5]=[C:6]([CH:21]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=1)=[O:8].[CH3:28][C:29]1[C:34](B(O)O)=[CH:33][CH:32]=[CH:31][N:30]=1>>[OH:27][C@@H:24]1[CH2:25][CH2:26][N:22]([C:3]2[C:2]([C:34]3[C:29]([CH3:28])=[N:30][CH:31]=[CH:32][CH:33]=3)=[CH:21][C:6]([C:7]([NH:9][C:10]3[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=3)=[O:8])=[CH:5][N:4]=2)[CH2:23]1

Participants

3

Reactant 2

HCID 201116472-Methylpyridine-3-boronic acidHCID 86702593(R)-5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide

Product 1

HCID 118195140HCID 118195140, compound

Procedure

The title compound was prepared in an analogous fashion to that described in Example 36 using (R)-5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 35.1) and (2-methylpyridin-3-yl)boronic acid to afford a white solid. UPLC-MS (condition 1) tR=1.71 min, m/z=459.0 [M+H]+, m/z=547.2 [M−H]−.

Workup

  1. customto afford a white solid

Sources & evidence

ORD record
ord-e9a35b102f614e088c8fb5cfed735104
Source dataset
uspto-grants-2016_03
Patent number
US09278981B2

Reaction notes

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