(Pyrimidin-5-yl)boronic acid → HCID 89907684, compound

HRID 923987Notes

Reaction equation

HRID 923987 reaction equation
[CH:1]12[N:9]([C:10]3[C:29](Br)=[CH:28][C:13]([C:14]([NH:16][C:17]4[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=4)=[O:15])=[CH:12][N:11]=3)[CH:5]([CH2:6][O:7][CH2:8]1)[CH2:4][O:3][CH2:2]2.[N:31]1[CH:36]=[C:35](B(O)O)[CH:34]=[N:33][CH:32]=1>>[CH:1]12[N:9]([C:10]3[C:29]([C:35]4[CH:36]=[N:31][CH:32]=[N:33][CH:34]=4)=[CH:28][C:13]([C:14]([NH:16][C:17]4[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=4)=[O:15])=[CH:12][N:11]=3)[CH:5]([CH2:6][O:7][CH2:8]1)[CH2:4][O:3][CH2:2]2

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 89907307HCID 89907307, compound

Product 1

HCID 89907684HCID 89907684, compound

Procedure

The title compound was prepared in an analogous fashion to that described in Example 133 using 6-(3,7-dioxa-9-azabicyclo[3.3.1]nonan-9-yl)-5-bromo-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 150.1) and pyrimidin-5-ylboronic acid to afford a solid. HPLC (Condition 4) tR=5.08 min, UPLC-MS (Condition 3) tR=1.00 min, m/z=488.2 [M+H]+.

Workup

  1. customto afford a solid

Sources & evidence

ORD record
ord-b92a4be0314e46258b54d6ae0616f2f9
Source dataset
uspto-grants-2016_03
Patent number
US09278981B2

Reaction notes

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