Diethyl Ether → [1-Benzyl-4-(2-fluorobenzyl)piperidin-4-yl)methanol

HRID 92401Notes

Reaction equation

HRID 92401 reaction equation
[Al+3:28].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][C:11]([C:14](=[O:15])[O:16][CH2:17][CH3:18])([CH2:19][c:20]2[c:21]([F:26])[cH:22][cH:23][cH:24][cH:25]2)[CH2:12][CH2:13]1.[CH3:33][CH2:34][O:35][CH2:36][CH3:37].[H-:27].[H-:30].[H-:31].[H-:32].[Li+:29]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][C:11]([CH2:14][OH:15])([CH2:19][c:20]2[c:21]([F:26])[cH:22][cH:23][cH:24][cH:25]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 3283Diethyl EtherHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 59833634Ethyl 1-benzyl-4-(2-fluorobenzyl)piperidine-4-carboxylate

Product 1

HCID 68961767[1-Benzyl-4-(2-fluorobenzyl)piperidin-4-yl)methanol

Sources & evidence

ORD record
ord-beafdbab7f7c44f7b909b20a2a076590
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…