反应详情

(R)-Methyl 6-(3-hydroxypyrrolidin-1-yl)-5-(pyrimidin-5-yl)nicotinate (Stage 170.2, 640 mg, 4.26 mmol) was added to 2 M NaOH (2 mL) and stirred 30 min at RT until complete dissolution. The RM was acidified (pH=2) with 2 M HCl and the solid which precipitated was filtered to afford the title compound as a white crystalline powder. HPLC (Condition 4) tR=2.19 min, UPLC-MS (Condition 7) m/z=287.1 [M+H]+.

1. customthe solid which precipitated
2. filtrationwas filtered