HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-6-chloropyridine-3-carboxylic acid → 5-bromo-6-chloro-N-(4-(2-chloro-1,1,2,2-tetrafluoroethyl)phenyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| Reactant | 4-(2-Chloro-1,1,2,2-tetrafluoroethyl)aniline | HCID 86702632 | — |
| Product | 5-bromo-6-chloro-N-(4-(2-chloro-1,1,2,2-tetrafluoroethyl)phenyl)nicotinamide | HCID 86702631 | — |
Reaction Steps
The title compound was prepared in an analogous fashion to that described in Stage 169.2 using 4-(2-chloro-1,1,2,2-tetrafluoroethyl)aniline (Stage 278.3) and 5-bromo-6-chloronicotinic acid to afford a beige crystalline powder. HPLC (Condition 4) tR=6.77 min, UPLC-MS (Condition 3) tR=1.31 min, m/z=444.8 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278981B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-4f70f995fd094f77a6b1ea63c8fefd66 |
| Source note | uspto-grants-2016_03 |