反应详情

Anthranilonitrile (10.0 grams, 85.0 mmol) was dissolved in 350 mL of acetic acid. To this was added 2,5-dimethoxytetrahydrofuran (11.0 mL, 85.0 mmol). This was stirred at reflux for 2 hours after which time the reaction mixture was pored into water and the product extracted with dichloromethane. The organic layer was washed with water, dried over sodium sulfate and chromatographed on a silica gel column using a mobile phase of 1:1 dichloromethane-hexane to afford the title compound as a white solid. NMR confirms structure.

1. temperatureat reflux for 2 hours after which time the reaction mixture
2. extractionthe product extracted with dichloromethane
3. washThe organic layer was washed with water
4. dry with materialdried over sodium sulfate
5. customchromatographed on a silica gel column