Water → Methyl 4-formyl-2-hydroxybenzoate

HRID 924654노트

반응식

HRID 924654 반응식
[CH:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([O:13]C)[CH:4]=1)=[O:2].[Al+3].[Cl-].[Cl-].[Cl-].O>C(Cl)Cl>[CH:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([OH:13])[CH:4]=1)=[O:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 6451240Aluminum(III) ChlorideHCID 18510332Methyl 4-formyl-2-methoxybenzoate

생성물 1

HCID 21626741Methyl 4-formyl-2-hydroxybenzoate수율 92%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A mixture of product from Step 2 (2.6 g, 13.4 mmol) and AlCl3 (3.6 g, 26.8 mmol) in anhydrous DCM (50 mL) was refluxed for 3 minutes. The resulting mixture was cooled and poured into water (100 mL), followed by a standard aqueous/DCM workup to give Intermediate 5 (2.2 g, yield 92%).

후처리

  1. temperaturewas refluxed for 3 minutes
  2. temperatureThe resulting mixture was cooled

출처 및 근거

ORD 기록
ord-f16cfadf1d404c26aaba3e81b3f12c51
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09283213B2

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