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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 924946Generated: October 30, 2026

1,3-Dibromobenzene → 3'-Bromo-2-Phenylacetophenone

https://huagongshe.com/reaction/924946

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-DibromobenzeneHCID 7927—
Reactant2-(3,4-Difluorophenyl)-1-phenylethanoneHCID 2758317—
Product3'-Bromo-2-PhenylacetophenoneHCID 275709347.7%

Reaction Steps

Followed the procedure described in Intermediate 12, starting from 1,3-dibromobenzene, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to give the desired 1-(3-bromophenyl)-2-phenylethanone (520 mg, yield 47.7%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09283229B2
Source datasetuspto-grants-2016_03
ORD IDord-15e0e3605e1c45ecb525737d7f26c2d4
Source noteuspto-grants-2016_03