1,3-Dibromobenzene → 3'-Bromo-2-Phenylacetophenone

HRID 924946Notes

Reaction equation

HRID 924946 reaction equation
F[C:2]1[CH:3]=[C:4]([CH2:9][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])[CH:5]=[CH:6][C:7]=1F.[Br:18]C1C=CC=C(Br)C=1>>[Br:18][C:14]1[CH:13]=[C:12]([C:10](=[O:11])[CH2:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=2)[CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 79271,3-DibromobenzeneHCID 27583172-(3,4-Difluorophenyl)-1-phenylethanone

Product 1

HCID 27570933'-Bromo-2-PhenylacetophenoneYield 47.7%

Procedure

Followed the procedure described in Intermediate 12, starting from 1,3-dibromobenzene, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to give the desired 1-(3-bromophenyl)-2-phenylethanone (520 mg, yield 47.7%).

Workup

  1. customwas purified by column chromatography (PE:EtOAc=100:1)

Sources & evidence

ORD record
ord-15e0e3605e1c45ecb525737d7f26c2d4
Source dataset
uspto-grants-2016_03
Patent number
US09283229B2

Reaction notes

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