反应详情

To a solution of N-methoxy-N-methylisonicotinamide (500 mg, 3.0 mmol) in anhydrous THF (10 mL) was added benzylmagnesium chloride (2 M in THF, 1.8 mL, 3.6 mmol) drop wise at −78° C. After being stirred at the temperature for 2 h, the reaction was quenched with NH4Cl aqueous solution, and extracted with EtOAc. The organic layer was dried over Na2SO4, concentrated in vacuo, and purified by column chromatography (PE:EtOAc=5:1) to give Intermediate 35 (60 mg, yield 10%).

1. customthe reaction was quenched with NH4Cl aqueous solution
2. extractionextracted with EtOAc
3. dry with materialThe organic layer was dried over Na2SO4
4. concentrationconcentrated in vacuo
5. custompurified by column chromatography (PE:EtOAc=5:1)