Hydrochloric Acid → HCID 21568243, compound

HRID 924998Notes

Reaction equation

HRID 924998 reaction equation
[C:1]([C:3]1[C:13]([O:14][CH2:15][CH3:16])=[CH:12][C:6]([C:7]([O:9]CC)=[O:8])=[CH:5][C:4]=1[O:17][CH2:18][CH3:19])#N.[OH-:20].[K+].Cl.[OH2:23]>>[CH2:18]([O:17][C:4]1[CH:5]=[C:6]([C:7]([OH:9])=[O:8])[CH:12]=[C:13]([O:14][CH2:15][CH3:16])[C:3]=1[C:1]([OH:23])=[O:20])[CH3:19]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 67060958HCID 67060958, compound

Product 1

HCID 21568243HCID 21568243, compound

Conditions

Temperature
130 °C

Procedure

A mixture of ethyl 4-cyano-3,5-diethoxybenzoate (1.0 g, 3.8 mmol) and KOH (5.0 g, 89.3 mmol) in water (30 mL) was stirred at 130° C. overnight. The mixture was acidified with aqueous HCl (2M) until pH=5. Solvent removed in vacuo and used for next step directly without further purification.

Workup

  1. customSolvent removed in vacuo
  2. customused for next step directly without further purification

Sources & evidence

ORD record
ord-a4a1c7436e6e45b688ebacd4fe7d1900
Source dataset
uspto-grants-2016_03
Patent number
US09283229B2

Reaction notes

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