Chlorodiphenylphosphine → HCID 178438974, compound

HRID 925048Notes

Reaction equation

[CH2:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[NH:19])[C:12]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=1)[CH2:2][CH3:3].C([Li])CCC.Cl[P:26]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=[N:19][P:26]([C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:12]1[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=1)[CH2:2][CH3:3]

Participants

Reactant 3

HCID 66180Chlorodiphenylphosphine

HCID 178418339Butyllithium

HCID 178438972HCID 178438972, compound

Product 1

HCID 178438974HCID 178438974, compound

Procedure

Procedure as described for NP Amidine XVII using the following amounts: 1.26 g of N1-(2-n-propylphenyl)-4-methylbenzamidine (5.0 mmol), 2.50 mL of 2.0 M butyllithium (5.0 mmol), 0.90 mL of chlorodiphenylphosphine (5.0 mmol). 1.76 g (74%) of light yellow solid was collected.

Workup

custom1.76 g (74%) of light yellow solid was collected

Sources & evidence

ORD record: ord-9df29efe9ea3409e91330b90ada193b3
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09283555B2

Reaction notes

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