HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → Tributyl(3-oxo-1,3,4,5,6,7-hexahydro-2-benzofuran-1-yl)phosphonium bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | 4,5,6,7-Tetrahydro-3-hydroxy-1(3H)-isobenzofuranone | HCID 10909777 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Tributyl(3-oxo-1,3,4,5,6,7-hexahydro-2-benzofuran-1-yl)phosphonium bromide | HCID 66966753 | — |
Reaction Steps
A solution of EXAMPLE 1A (3 g) in acetic acid (10 mL) at ambient temperature was treated with tri-n-butyl phosphine (4.81 mL) and 33% hydrobromic acid in acetic acid (3.34 mL), heated at reflux for 21 hours, cooled and concentrated. The concentrate was purified by flash chromatography on silica gel with 10% methanol in dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09283222B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-b531f3878562488991cab57885e0b601 |
| Source note | uspto-grants-2016_03 |