反应详情

A solution of EXAMPLE 1A (3 g) in acetic acid (10 mL) at ambient temperature was treated with tri-n-butyl phosphine (4.81 mL) and 33% hydrobromic acid in acetic acid (3.34 mL), heated at reflux for 21 hours, cooled and concentrated. The concentrate was purified by flash chromatography on silica gel with 10% methanol in dichloromethane.

1. temperatureheated
2. temperatureat reflux for 21 hours
3. temperaturecooled
4. concentrationconcentrated
5. customThe concentrate was purified by flash chromatography on silica gel with 10% methanol in dichloromethane