反应详情

To a solution of EXAMPLE 1B (3.05 g) in dichloromethane (30 mL) was added 2-fluoro-5-formylbenzonitrile (1.08 g) and triethylamine (1.02 mL). The mixture was stirred at ambient temperature for 16 hours and concentrated. The concentrate was partitioned between ethyl acetate and brine. The organic layer was washed with brine and concentrated. The concentrate was purified by flash chromatography on silica gel with 50% ethyl acetate in hexane.

1. concentrationconcentrated
2. customThe concentrate was partitioned between ethyl acetate and brine
3. washThe organic layer was washed with brine
4. concentrationconcentrated
5. customThe concentrate was purified by flash chromatography on silica gel with 50% ethyl acetate in hexane