Trifluoroacetic acid → Trifluoroacetic acid

HRID 925074Notes

Reaction equation

HRID 925074 reaction equation
[O:1]=[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([CH2:12][CH:13]2[CH2:18][N:17](C(OCC3C=CC=CC=3)=O)[CH2:16][CH2:15][N:14]2C(OC(C)(C)C)=O)=[N:4][NH:3]1.[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]>>[NH:14]1[CH2:15][CH2:16][NH:17][CH2:18][CH:13]1[CH2:12][C:5]1[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=2[C:2](=[O:1])[NH:3][N:4]=1.[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69044992HCID 69044992, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 69043912HCID 69043912, compound

Procedure

A solution of EXAMPLE 258 (35 mg, 0.1 mmol) in trifluoroacetic acid (5 ml) was stirred at room temperature for 1 hour, and was concentrated. The residue was purified by HPLC (Zorbax® C-18 ODS packing material [Agilent Technologies, Santa Clara, Calif.], 0.1% trifluoroacetic acid/CH3CN/H2O) to provide the title compound as a trifluoroacetic acid salt. MS (DCI/NH3) m/z 249 (M+H)+.

Workup

  1. concentrationwas concentrated
  2. customThe residue was purified by HPLC (Zorbax® C-18 ODS packing material [Agilent Technologies, Santa Clara, Calif.], 0.1% trifluoroacetic acid/CH3CN/H2O)

Sources & evidence

ORD record
ord-bc556f4024c34ce889c05aa1a247eeb6
Source dataset
uspto-grants-2016_03
Patent number
US09283222B2

Reaction notes

Loading…