Ammonia → HCID 69045351, compound

HRID 925086Notes

Reaction equation

HRID 925086 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]2[C:14]3[N:23]=[CH:22][CH:21]=[CH:20][C:15]=3[C:16](=[O:19])[NH:17][N:18]=2)=[CH:8][C:3]=1[C:4](OC)=[O:5].[NH3:24]>CO>[F:1][C:2]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]2[C:14]3[N:23]=[CH:22][CH:21]=[CH:20][C:15]=3[C:16](=[O:19])[NH:17][N:18]=2)=[CH:8][C:3]=1[C:4]([NH2:24])=[O:5]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 69044484HCID 69044484, compound

Product 1

HCID 69045351HCID 69045351, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of EXAMPLE 462A (1 g, 3.2 mmol) in 7N ammonia in methanol (5 ml) was heated at 70° C. overnight, and cooled to room temperature. The solid was collected by filtration, washed with methanol and dried to provide the title compound. MS (DCI/NH3) m/z 299 (M+H)+.

Workup

  1. filtrationThe solid was collected by filtration
  2. washwashed with methanol
  3. customdried

Sources & evidence

ORD record
ord-b1edb49122c94178a0bfca2da6ce5092
Source dataset
uspto-grants-2016_03
Patent number
US09283222B2

Reaction notes

Loading…