1,4-Dioxane hydrochloride → HCID 86725313, compound

HRID 925201Notes

Reaction equation

HRID 925201 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:27][CH2:26][C:10]2[C:11]3[C:12](O)([C:19]4[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=4)[CH2:13][CH2:14][C:15]=3[C:16]([I:18])=[CH:17][C:9]=2[CH2:8][CH2:7]1)=[O:5])[CH3:2].[ClH:28].O1CCOCC1>>[ClH:28].[CH2:1]([O:3][C:4]([N:6]1[CH2:27][CH2:26][C:10]2[C:11]3[C:12]([C:19]4[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=4)=[CH:13][CH2:14][C:15]=3[C:16]([I:18])=[CH:17][C:9]=2[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86725312HCID 86725312, compound

Product 1

HCID 86725313HCID 86725313, compound

Conditions

Temperature
60 °C

Procedure

Into a glass vial, the product from step (a) (0.38 mmol) dissolved in 4N HCl/dioxane (2 ml) was added. The reaction mixture was stirred at 60° C. for 1 h. The mixture was cooled to room temperature and the solvent was evaporated in vacuo to give sub-titled compound as a brown solid that was used without further purification. MS: ESI (positive): 461 (M+1).

Workup

  1. additionwas added
  2. temperatureThe mixture was cooled to room temperature
  3. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-ad41c2e8542c4c1babf0469227da187c
Source dataset
uspto-grants-2016_03
Patent number
US09284277B2

Reaction notes

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