反应详情

Ethyl 5-acetyl-1H-pyrazole-3-carboxylate (0.050 g, 0.274 mmol) was dissolved in EtOH (5 mL) and treated with a 2 M solution of NaOH (0.5 mL, 1 eq.) at reflux temperature for 3 h. Solvent was evaporated to dryness and the residue dissolved in H2O. After treatment with 2M HCl the resulting precipitate was extracted with DCM. The organic phase was dried on Na2SO4 and concentrated to dryness to give the title compound (37 mg, 87% yield) as a white solid.

1. temperatureat reflux temperature for 3 h
2. customSolvent was evaporated to dryness
3. dissolutionthe residue dissolved in H2O
4. extractionAfter treatment with 2M HCl the resulting precipitate was extracted with DCM
5. customThe organic phase was dried on Na2SO4
6. concentrationconcentrated to dryness