Sodium Hydroxide → 3-acetyl-1H-pyrazole-5-carboxylic acid

Participants

Reaction Steps

Ethyl 5-acetyl-1H-pyrazole-3-carboxylate (0.050 g, 0.274 mmol) was dissolved in EtOH (5 mL) and treated with a 2 M solution of NaOH (0.5 mL, 1 eq.) at reflux temperature for 3 h. Solvent was evaporated to dryness and the residue dissolved in H2O. After treatment with 2M HCl the resulting precipitate was extracted with DCM. The organic phase was dried on Na2SO4 and concentrated to dryness to give the title compound (37 mg, 87% yield) as a white solid.

Provenance & Evidence