Dimethylformamide dimethyl acetal → HCID 70911567, compound

HRID 925410Notes

Reaction equation

HRID 925410 reaction equation
[C:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=2)[N:7]=[C:6]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:5]=1)(=[O:3])[CH3:2].CO[CH:25](OC)[N:26]([CH3:28])[CH3:27]>C1(C)C=CC=CC=1>[CH3:25][N:26]([CH3:28])/[CH:27]=[CH:2]/[C:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=2)[N:7]=[C:6]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:5]=1)=[O:3]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 70873291HCID 70873291, compound

Product 1

HCID 70911567HCID 70911567, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
140 °C

Procedure

To a solution of ethyl 5-acetyl-1-(3-methoxy-benzyl)-1H-pyrazole-3-carboxylate (300 mg, 1 mmol) in 2 mL toluene, 240 mg (2 mmol) of N,N-dimethylformamide dimethyl acetal were added. The mixture was stirred for 18 h at 140° C. The volatiles were removed under vacuum to afford the title compound in quantitative yield.

Workup

  1. customThe volatiles were removed under vacuum

Sources & evidence

ORD record
ord-a3f46f598ab84a279fe449ad12c47859
Source dataset
uspto-grants-2016_03
Patent number
US09284298B2

Reaction notes

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