Potassium Cyanide → HCID 16789189, compound

HRID 925434Notes

Reaction equation

HRID 925434 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8](=O)[CH3:9])[CH:5]=[CH:6][CH:7]=1.[NH4+:11].[Cl-].[C-:13]#[N:14].[K+]>N>[NH2:11][C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)([CH3:9])[C:13]#[N:14]

Participants

5

Reactant 3

HCID 9032Potassium CyanideHCID 165023'-BromoacetophenoneHCID 25517Ammonium Chloride

Product 1

HCID 16789189HCID 16789189, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

A mixture of 1-(3-bromo-phenyl)-ethanone (10 g, 50 mmol), NH4Cl (6.4 g, 100 mmol) and KCN (6.5 g, 100 mmol) was dissolved in ammonia (200 ml). The solution was stirred at room temperature for 3 days. The mixture was extracted with diethylether (3×300 ml). The organic phase was washed with water and brine, dried with Na2SO4 and concentrated in vacuo to yield the title compound (also containing some unreacted starting material).

Workup

  1. extractionThe mixture was extracted with diethylether (3×300 ml)
  2. washThe organic phase was washed with water and brine
  3. dry with materialdried with Na2SO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-127bbafa164947f19b3cb44afdfa39e1
Source dataset
uspto-grants-2016_03
Patent number
US09284284B2

Reaction notes

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