反应详情

A mixture of 1-(3-bromo-phenyl)-ethanone (10 g, 50 mmol), NH4Cl (6.4 g, 100 mmol) and KCN (6.5 g, 100 mmol) was dissolved in ammonia (200 ml). The solution was stirred at room temperature for 3 days. The mixture was extracted with diethylether (3×300 ml). The organic phase was washed with water and brine, dried with Na2SO4 and concentrated in vacuo to yield the title compound (also containing some unreacted starting material).

1. extractionThe mixture was extracted with diethylether (3×300 ml)
2. washThe organic phase was washed with water and brine
3. dry with materialdried with Na2SO4
4. concentrationconcentrated in vacuo