反应详情

A mixture of N-[1-(5-bromo-2-fluoro-phenyl)-2-hydroxy-1-hydroxymethyl-ethyl]-2-chloro-acetamide (6.34 g, 18.62 mmol) and potassium tert.-butoxide (2.09 g, 18.62 mmol) in 62 ml tBuOH was refluxed for 30 min. 19 ml 1 N HCl and water were added and the aqueous layer was extracted with EtOAc. The organic layer was washed with brine, dried with MgSO4 and evaporated. The crude product was recrystallized in Hex/EtOAc to provide the title compound as an off-white solid.

1. temperaturewas refluxed for 30 min
2. extractionthe aqueous layer was extracted with EtOAc
3. washThe organic layer was washed with brine
4. dry with materialdried with MgSO4
5. customevaporated
6. customThe crude product was recrystallized in Hex/EtOAc