反应详情

5-Bromo-3-methyl-pyridine-2-carboxylic acid ethyl ester (2.44 g, 10 mmol) was dissolved in NH3/MeOH (50 ml) and heated to reflux for 3 days. The reaction mixture was concentrated to give the desired product as a pink solid (2.05 g, 9.6 mmol).

1. temperatureheated
2. temperatureto reflux for 3 days
3. concentrationThe reaction mixture was concentrated