HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia methanol → 5-Bromo-3-methylpyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia methanol | HCID 21705897 | — |
| Reactant | Ethyl 5-bromo-3-methylpicolinate | HCID 53418426 | — |
| Product | 5-Bromo-3-methylpyridine-2-carboxamide | HCID 68522513 | — |
Reaction Steps
5-Bromo-3-methyl-pyridine-2-carboxylic acid ethyl ester (2.44 g, 10 mmol) was dissolved in NH3/MeOH (50 ml) and heated to reflux for 3 days. The reaction mixture was concentrated to give the desired product as a pink solid (2.05 g, 9.6 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284284B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-ec17b29b8ff54250b0977df129b33a17 |
| Source note | uspto-grants-2016_03 |