Trifluoroacetic acid → HCID 59484880, compound

HRID 925481Notes

Reaction equation

HRID 925481 reaction equation
C(OC(=O)[NH:7][CH2:8]/[CH:9]=[CH:10]\[C:11]1[CH:12]=[N:13][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][N:24]3[C:29](=[O:30])[CH:28]=[CH:27][C:26]([C:31]4[CH:36]=[C:35]([F:37])[C:34]([F:38])=[C:33]([F:39])[CH:32]=4)=[N:25]3)[CH:18]=2)=[N:15][CH:16]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:7][CH2:8]/[CH:9]=[CH:10]/[C:11]1[CH:12]=[N:13][C:14]([C:17]2[CH:18]=[C:19]([CH:20]=[CH:21][CH:22]=2)[CH2:23][N:24]2[C:29](=[O:30])[CH:28]=[CH:27][C:26]([C:31]3[CH:36]=[C:35]([F:37])[C:34]([F:38])=[C:33]([F:39])[CH:32]=3)=[N:25]2)=[N:15][CH:16]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86645315HCID 86645315, compound

Product 1

HCID 59484880HCID 59484880, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

48.3 28 mg (0.051 mmol) of tert-butyl[(Z)-3-(2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yl)allyl]carbamate are dissolved in 4 ml of dichloromethane, and 79 μl (1.02 mmol) of trifluoroacetic acid are added. The reaction mixture is stirred at room temperature for 15 h and evaporated. The residue is purified by means of preparative HPLC; yield: 11 mg of “A284” trifluoroacetate; HPLC: Rt=2.64 min (method C); LC-MS: 450 (M+H).

Workup

  1. customevaporated
  2. customThe residue is purified by means of preparative HPLC

Sources & evidence

ORD record
ord-9d35f60cdc5543faacc6c732f0e773af
Source dataset
uspto-grants-2016_03
Patent number
US09284300B2

Reaction notes

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