Water → 8-(6-Chloro-pyridin-3-yl)-1-propyl-3,7-dihydro-purine-2,6-dione

HRID 925557Notes

Reaction equation

[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4](=[O:12])[C:3]=1[NH:13][C:14](=O)[C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[N:17][CH:16]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.O>CN(C=O)C>[Cl:21][C:18]1[N:17]=[CH:16][C:15]([C:14]2[NH:13][C:3]3[C:4](=[O:12])[N:5]([CH2:9][CH2:10][CH3:11])[C:6](=[O:8])[NH:7][C:2]=3[N:1]=2)=[CH:20][CH:19]=1

Participants

Conditions

Temperature: 101 °C

Procedure

A mixture of N-(6-Amino-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-6-chloro-nicotinamide (2.47 g, 7.6 mmol), P2O5 was taken in DMF (20 ml) and heated at 100-102° C. for 30 minute. Reaction mixture was cooled to room temperature and cold water (60 ml) was added. Precipitated solid was filtered off to get 8-(6-Chloro-pyridin-3-yl)-1-propyl-3,7-dihydro-purine-2,6-dione as pale yellow solid (1.8 g, 77%).

Workup

customReaction mixture
temperaturewas cooled to room temperature
customPrecipitated solid
filtrationwas filtered off

Sources & evidence

ORD record: ord-9e6e7bd164804b48b178f04e2097dc84
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09284316B2

Reaction notes

Loading…