3-Methoxyaniline → 1-(2-Amino-4-chloro-5-methoxyphenyl)ethanone

HRID 925934Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[O:9][CH3:10])[NH2:5].C[O:12][C:13]1C=CC=C(N)[CH:14]=1>>[NH2:5][C:4]1[CH:3]=[C:2]([Cl:1])[C:8]([O:9][CH3:10])=[CH:7][C:6]=1[C:13](=[O:12])[CH3:14]

Participants

Reactant 2

HCID 108243-Methoxyaniline

HCID 214413-Chloro-4-methoxyaniline

Product 1

HCID 666504821-(2-Amino-4-chloro-5-methoxyphenyl)ethanoneYield 50%

Procedure

1-(2-Amino-4-chloro-5-methoxy-phenyl)-ethanone 201g was synthesized from 3-chloro-4-methoxy-aniline 215g as a brown solid in 50% yield, according to the procedure as described for compound 215a. MS (ESI, EI+): m/z=200 (MH+).

Sources & evidence

ORD record: ord-4ff61289c79e4b409326492a931081be
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09284307B2

Reaction notes

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