4-(Propan-2-yl)-1,3-thiazole-2-carbonyl chloride → 4-Cyclopropyl-thiazole-2-carbonyl chloride

HRID 925973Notes

Reaction equation

HRID 925973 reaction equation
C1(C2N=C(C([O-])=O)SC=2)CC1.[Li+].[CH:13]([C:16]1[N:17]=[C:18]([C:21]([Cl:23])=[O:22])[S:19][CH:20]=1)([CH3:15])[CH3:14]>>[CH:13]1([C:16]2[N:17]=[C:18]([C:21]([Cl:23])=[O:22])[S:19][CH:20]=2)[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 575787964-(Propan-2-yl)-1,3-thiazole-2-carbonyl chlorideHCID 68792487Lithium 4-cyclopropylthiazole-2-carboxylate

Product 1

HCID 594348264-Cyclopropyl-thiazole-2-carbonyl chloride

Procedure

Compound 267a was synthesized from compound 266a (3 g, 1 eq.) as a brown solid in quantitative yield, following the procedure as described for compound 214. MS (ESI, EI+): m/z=170 (MH+).

Sources & evidence

ORD record
ord-55a82b560cde458ebfd38cb2e38cd7f2
Source dataset
uspto-grants-2016_03
Patent number
US09284307B2

Reaction notes

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