Hydrogen chloride-ethyl acetate → HCID 178501217, compound

HRID 926028Notes

Reaction equation

HRID 926028 reaction equation
C(OC([N:8]([CH:19]([CH3:21])[CH3:20])[C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:22].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:22].[CH:19]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][CH2:10]1)([CH3:21])[CH3:20]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178501240HCID 178501240, compound

Product 1

HCID 178501217HCID 178501217, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of 1.8 g of methyl trans-4-[(tert-butoxycarbonyl)(isopropyl)amino]cyclohexane carboxylate and 20 mL of ethyl acetate were added 20 mL of a 4.0 M hydrogen chloride/ethyl acetate solution, followed by stirring at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure to obtain 1.18 g of methyl trans-4-(isopropylamino)cyclohexane carboxylate hydrochloride as a colorless solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a45e1760832e48a89b27d4a24042245b
Source dataset
uspto-grants-2016_03
Patent number
US09284295B2

Reaction notes

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